
Missouri – Missouri Old Route 66
4.0 New France & Midlands – Saint Louis Route 66

4.1 Cahokia Mounds (Illinois)
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- Monks Mound
- Twin Mounds
- Grand Plaza
- Mound 72
- Woodhenge


4.2 French Colonial Illinois Country
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- Cahokia (population: 12,000)
- Cahokia Courthouse
- Holy Family Log Church
- Jarrot Mansion
- Prairie Du Rocher (population: 500)
- Fort de Chartres State Historic Site
- Creole House
- Ellis Grove (population: 300)
- Pierre Menard Home State Historic Site
- Fort Kaskaskia State Historic Site
- Felix Valle House State Historic Site
- Modoc Rock Shelter
- Kaskaskia (population: 10-20-ish)
- Kaskaskia Bell State Memorial
- Cahokia (population: 12,000)

4.3 Ste. Geneviève
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- Population: 5,000
- Ste. Geneviève National Historical Park
- Jacques Guibourd Historic House
- Beauvais-Amoureux House
- Janis-Ziegler Home (Greentree Tavern)
- Felix Valle House State Historic Site
- The Centre for French Colonial Life & the Bolduc House Museum

4.4 Saint Louis Downtown – Gateway Arch
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- City population: 275,000; peak city population 1950: 857,000; metro: 2.8 million
- Gateway to the West
- Mound City
- Gateway Arch National Park (former Jefferson National Expansion Memorial)
- Gateway Arch
- Old Courthouse
- Luther Ely Smith Square
- Basilica of Saint Louis, King of France
- Gateway Arch Riverboats
- National Blues Museum
- Sugarfire Smoke House Barbecue

4.5 Saint Louis Downtown West & Lafayette Park
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- Downtown West
- Saint Louis Union Station
- The Wheel
- Aloe Plaza
- United States Postal Service
- Saint Louis City Municipal Court
- Memorial Plaza
- Stifel Theatre
- Soldiers Memorial Military Museum
- Eternal Flame Park
- Saint Louis City Hal
- Washington Square Park
- Poelker Park
- Serra Sculpture Park
- Kiener Plaza Park
- Ballpark Pizza (Saint Louis style thin crust pizza)
- City Museum
- Lafayette Square
- Lafayette Park
- Park Avenue Coffee (gooey butter cake)
- Downtown West

4.6 Saint Louis Forest Park
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- Forest Park (centennial of the Louisiana Purchase Exposition of 1904 – the St. Louis World’s Fair site)
- City Art Museum – Apotheosis of Saint Louis
- Jewel Box Conservatory
- Colonial Daughter Fountain
- World’s Fair Pavilion
- Nathan Frank Bandstand in Pagoda Lake
- Jefferson Memorial – Missouri History Museum
- George Washington University

4.7 Saint Louis – University City – Delmar Loop
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- Salt + Smoke Barbecue
- Fitz’s Root Beer Floats
- St. Louis Walk of Fame
- Blueberry Hill (famous Chuck Berry venue)
- Chuck Berry Statue

4.8 Metro Saint Louis
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- The Fabulous Fox Theatre
- Ulysses S Grant National Historic Site
- National Museum of Transportation
- Magic House – St. Louis Children’s Museum
- St. Louis Car Museum
- Ted Drewes Frozen Custard
- Donut Drive-In